1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-9-61-a 10.15844/pedneurbriefs-9-8-8 Infectious Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Herpesvirus-6 Infection and First Febrile Seizures http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1995 01 06 2016 9 8 61 61 Copyright: © 1995 The Author(s) 1995 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Human herpesvirus-6 infection in children with first febrile seizures

The association between acute human herpesvirus-6 (HHV-6) infection and first febrile convulsions was investigated prospectively in 42 children evaluated by virologic and serologic methods at the North Shore University Hospital-Cornell University Medical College, Manhasset, New York.

 Human Herpesvirus-6 Febrile Convulsions Encephalopathy

The association between acute human herpesvirus-6 (HHV-6) infection and first febrile convulsions was investigated prospectively in 42 children evaluated by virologic and serologic methods at the North Shore University Hospital-Cornell University Medical College, Manhasset, New York. Primary HHV-6 infection was documented by viral culture in 8 (19%), and fourfold rises in HHV-6 titer were present in 9 (26%) of 34 children whose blood was analyzed for acute and convalescent HHV-6 titers. The majority (10 of 11) HHV-6 cases were less than 24 months of age, and 3/11 had roseola. Viral isolation in CSF, attempted in 29, including 7 with evidence of HHV-6 illness, was negative. [1]

COMMENT. Acute HHV-6 infection is a significant factor in the etiology of fever and convulsions in young children. Seizures associated with exanthem subitum and HHV-6 infection are not always simple in type, however. They are occasionally prolonged and complex and a manifestation of encephalitis or encephalopathy. See Progress in Pediatric Neurology II, 1994, Chicago, PNB Publishers, for a report and comment on HHV-6 infection, exanthem subitum, and encephalitis/encephalopathy. HHV-6 virus DNA was detected in the cerebrospinal fluid of 6 infants with exanthem subitum, 3 having a pleocytosis and elevated protein in the CSF. [2]

 Barone SR Kaplan MH Krilov LR Human herpesvirus-6 infection in children with first febrile seizures J Pediatr 1995 Jul 127 1 95 97 10.1016/S0022-3476(95)70263-6 7608818 Suga S Yoshikawa T Asano Y Kozawa T Nakashima T Kobayashi I Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications Ann Neurol 1993 Jun 33 6 597 603 10.1002/ana.410330607 8388679