1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-9-60-b 10.15844/pedneurbriefs-9-8-6 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Cerebral Cortical Dysgenesis and Epilepsy in Adults http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1995 01 06 2016 9 8 60 60 Copyright: © 1995 The Author(s) 1995 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients

The clinical, EEG and neuroimaging features in 100 adult patients with cerebral cortical dysgenesis (CD) were reviewed at the National Hospital for Neurology and Neurosurgery, St Mary’s Hospital, London, and the National Society for Epilepsy, Chalfont St Peter, Gerrards Cross, UK.

 Cerebral Cortical Dysgenesis Cryptogenic Epilepsy Status Epilepticus

The clinical, EEG and neuroimaging features in 100 adult patients with cerebral cortical dysgenesis (CD) were reviewed at the National Hospital for Neurology and Neurosurgery, St Mary’s Hospital, London, and the National Society for Epilepsy, Chalfont St Peter, Gerrards Cross, UK. Patients had medically refractory epilepsy with onset at a median age of 10 years. Only 15% had a history of status epilepticus. Diagnosis was by neuroimaging in 70. EEGs were abnormal in 95%. Of 35 patients treated by surgery, 15 were completely seizure-free. Demonstration of subtle forms of CD by MRI lessen the incidence of cryptogenic epilepsy in adult patients. [1]

COMMENT. The heterogeneity of abnormalities associated with CD in adults with epilepsy, as listed in the title of this article, was associated with varied clinical, EEG and MRI features. Compared to children with epilepsy and CD, these adult patients had a relatively low frequency of delayed milestones (12%), mental retardation (11%) and neurologic deficits (17%).

 Raymond AA Fish DR Sisodiya SM Alsanjari N Stevens JM Shorvon SD Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients Brain 1995 Jun 118 Pt 3 629 660 10.1093/brain/118.3.629 7600083