1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-9-21-b 10.15844/pedneurbriefs-9-3-8 Learning and Behavior Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Behavior Disorders and Noonan’s Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 03 1995 01 06 2016 9 3 21 21 Copyright: © 1995 The Author(s) 1995 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Behavioural aspects and psychiatric findings in Noonan’s syndrome

The behavioral phenotype and psychiatric symptoms of 21 children with Noonan’s syndrome are reported from the Departments of Child and Adolescent Psychiatry, and Clinical Genetics, Royal Manchester Children’s Hospital, UK.

 Psychiatric Symptoms Pregnancy Complications Echolalia

The behavioral phenotype and psychiatric symptoms of 21 children with Noonan’s syndrome are reported from the Departments of Child and Adolescent Psychiatry, and Clinical Genetics, Royal Manchester Children’s Hospital, UK. Ages ranged from 2 to 16 years (median, 9 years). Non-behavioral abnormalities included pregnancy complications (52%), short stature (71%), visual problems (57%), and language impairment (43%). Behavioral abnormalities in >50% of the group included clumsiness (71%), faddy eating habits (67%), fidgeting (62%), stubbornness (62%), echolalia (52%), euphoria (52%), and irritability (52%). On the Child Behavior Checklist for parent reported psychiatric abnormalities, only social relationships and attention span were disturbed, and these are non-specific. A behavioral profile for Noonan’s syndrome is suggested by these findings but compared to sibling controls, the abnormalities were not statistically significant. [1]

COMMENT. Noonan’s syndrome is a genetic disorder characterized by pulmonary stenosis, facial abnormalities, short stature, and learning difficulties. Few studies have emphasized behavioral abnormalities and a behavioral phenotype has not been delineated. The above behavioral characteristics may be helpful in diagnosis, counselling, and treatment. The association of Noonan’s syndrome and neurofibromatosis has been described. (Listernick, Charrow, 1990; see Progress in Ped Neur II, 1994, p377).

 Wood A Massarano A Super M Harrington R Behavioural aspects and psychiatric findings in Noonan’s syndrome Arch Dis Child 1995 Feb 72 2 153 5 7702381 10.1136/adc.72.2.153