1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-9-06-b 10.15844/pedneurbriefs-9-1-9 Attention and Learning Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Dyslexia and Small Genu of Corpus Callosum http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1995 01 06 2016 9 1 6 7 Copyright: © 1995 The Author(s) 1995 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dyslexia and corpus callosum morphology

Corpus callosum morphology was studied by MRI in 16 children (mean age, 9.7 yrs) with developmental dyslexia and matched controls at the Center for Clinical and Developmental Neuropsychology, University of Georgia, Athens, and the Department of Neurology, Medical College of Georgia, Augusta, and the Athens Magnetic Imaging.

 Familial Left-Handedness Dyslexic Children Athens Magnetic Imaging

Corpus callosum morphology was studied by MRI in 16 children (mean age, 9.7 yrs) with developmental dyslexia and matched controls at the Center for Clinical and Developmental Neuropsychology, University of Georgia, Athens, and the Department of Neurology, Medical College of Georgia, Augusta, and the Athens Magnetic Imaging. The genu of the corpus callosum was significantly smaller in the dyslexic children. Familial left-handedness, and ADD with and without hyperactivity distinguished the dyslexic children from controls. [1]

COMMENT. Studies of MRI morphology of the corpus callosum in monozygotic twins at Dartmouth Medical School Program in Cognitive Neuroscience showed wide variations in size and shape of the human corpus callosum. Measurements revealed greater similarity in twin pairs than in randomly paired controls [2]. The anatomy of the corpus callosum appears to be under genetic control as well as being influenced by nongenetic factors. How much this natural variation in size of the corpus callosum influenced the results of the above study in dyslexia is debatable. (see Progress in Pediatric Neurology I, PNB Publ, 1991, pp 168-9).

 Hynd GW Hall J Novey ES Eliopulos D Black K Gonzalez JJ Dyslexia and corpus callosum morphology Arch Neurol 1995 Jan 52 1 32 8 7826273 10.1001/archneur.1995.00540250036010 Oppenheim JS Skerry JE Tramo MJ Gazzaniga MS Magnetic resonance imaging morphology of the corpus callosum in monozygotic twins Ann Neurol 1989 Jul 26 1 100 4 2774498 10.1002/ana.410260117