1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-9-07-a 10.15844/pedneurbriefs-9-1-10 Attention and Learning Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Silver-Russell Syndrome and Cognitive Disorders http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1995 01 06 2016 9 1 7 7 Copyright: © 1995 The Author(s) 1995 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cognitive abilities associated with the Silver-Russell syndrome

Cognitive abilities of 20 boys and 5 girls, aged 6 to 11 years, with Silver-Russell syndrome were investigated at the Prince of Wales Hospital, Shatin, Hong Kong, the Institute of Child Health, and Middlesex Hospital, London, UK.

 Silver-Russell Syndrome Speech Therapy Cognitive Abilities

Cognitive abilities of 20 boys and 5 girls, aged 6 to 11 years, with Silver-Russell syndrome were investigated at the Prince of Wales Hospital, Shatin, Hong Kong, the Institute of Child Health, and Middlesex Hospital, London, UK. The mean full scale IQ was 86, and 32% scored <70. Reading comprehension was 24 months below chronological age in 40%. Speech therapy was required in 48%. IQ scores were positively correlated with growth in head circumference. [1]

COMMENT. Features of Silver-Russell syndrome include low birth weight, short stature, body asymmetry, clinodactyly, and craniofacial dysmorphism - small triangular face, large forehead, small chin, shark’s mouth, and low set ears. The present study adds cognitive disorders to the list of features. Intrauterine growth retardation of Silver-Russell syndrome beginning early in pregnancy results in reduction in both birth weight and length. In this “symmetrical” type of growth retardation, in utero brain development is more likely to be affected than when growth retardation begins late in pregnancy.

 Lai KY Skuse D Stanhope R Hindmarsh P Cognitive abilities associated with the Silver-Russell syndrome Arch Dis Child 1994 Dec 71 6 490 6 7726606 10.1136/adc.71.6.490