1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-71-b 10.15844/pedneurbriefs-8-9-12 Vascular Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Safety of Phenobarbital in Neonates with HIE http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 09 1994 01 06 2016 8 9 71 72 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress

Phenobarbital treatment (20 mg/kg iv) had no significant effect on cerebral blood flow or blood pressure and heart rate, measured 60 min after a loading dose, in 7 term newborn infants with mild to moderate hypoxic ischemic encephalopathy examined in the Dept of Paediatrics, Alborg Hospital, Denmark.

 Phenobarbital Fetal Distress Periventricular Hemorrhage

Phenobarbital treatment (20 mg/kg iv) had no significant effect on cerebral blood flow or blood pressure and heart rate, measured 60 min after a loading dose, in 7 term newborn infants with mild to moderate hypoxic ischemic encephalopathy examined in the Dept of Paediatrics, Alborg Hospital, Denmark. Phenobarbital imposed no risk of cerebrovascular damage in newborns with fetal distress. [1]

COMMENT. Phenobarbital is the most commonly used anticonvulsant in neonates and has been advocated in the prevention of periventricular hemorrhage in preterm infants. This demonstration of the safety of phenobarbital in neonates with HIE is encouraging and should offset in part the poor rating the drug has received in some febrile seizure studies.

 Andersen K Jensen KA Ebbesen F The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress Eur J Pediatr 1994 Aug 153 8 584 587 10.1007/BF02190664 7957406