1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-58-b 10.15844/pedneurbriefs-8-8-3 Neurofibromatosis Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Infantile Spasms and NF-1 http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1994 01 06 2016 8 8 58 58 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Infantile spasms in patients with neurofibromatosis type 1

Two patients, ages 7 and 2 years, with neurofibromatosis type 1 complicated by infantile spasms are reported from the Pediatric Institutes, Siena and Catania, Italy.

 Neurofibromatosis Type 1 Infantile Spasms Tuberous Sclerosis

Two patients, ages 7 and 2 years, with neurofibromatosis type 1 complicated by infantile spasms are reported from the Pediatric Institutes, Siena and Catania, Italy. ACTH and anticonvulsants were ineffective. Both children were mentally retarded and one had UBOs on MRI. The authors believe that the association of NF-1 and infantile spasms is not a coincidence and infantile spasms should be included among the clinical manifestations of NF-1. [1]

COMMENT. The authors cite 7 additional cases of infantile spasms with NF-1 in the literature, the first reference to this association originating from Japan [2]. They include a report by Motte et al of 15 cases, all responsive to steroids and having a good mental outcome (1992, unpublished data). A reference to 2 cases reported in a population study of 135 patients with NF-1 in Wales was omitted [3]. Infantile spasms and hypsarrhythmia occur much less frequently with NF-1 than in tuberous sclerosis, but the association is more prevalent than expected.

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