1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-63-b 10.15844/pedneurbriefs-8-8-11 Movement Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Clomipramine for Compulsive Tics http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1994 01 06 2016 8 8 63 63 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

Reduction of adventitious movements and compulsions during clomipramine treatment (25 mg - 200 mg daily at bedtime) in five prepubertal, autistic, retarded boys is reported from the Division of Child and Adolescent Psychiatry, Bellevue Hospital and New York University Medical Center, New York.

 Clomipramine Dyskinesia Tics

Reduction of adventitious movements and compulsions during clomipramine treatment (25 mg - 200 mg daily at bedtime) in five prepubertal, autistic, retarded boys is reported from the Division of Child and Adolescent Psychiatry, Bellevue Hospital and New York University Medical Center, New York. Ratings were conducted before, after 2 and 4 weeks treatment, and every 4 weeks. All three classes of movements responded to medication: general dyskinesia, akathisia, and tics. Medications were administered in a nonblind trial in clinical emergencies to extremely disturbed patients with severe environmental and familial stresses. [1]

COMMENT. Medicated autistic patients frequently have akathisia and tics. The differentiation of various adventitious movements in a heterogeneous group of patients is difficult, and specificity of response to treatment is limited.

 Brasic JR Barnett JY Kaplan D Sheitman BB Aisemberg P Lafargue RT Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation Neurology 1994 Jul 44 7 1309 1312 10.1212/WNL.44.7.1309 8035936