1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-51-b 10.15844/pedneurbriefs-8-7-5 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Cortical Hypometabolism in West’s Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1994 01 06 2016 8 7 51 51 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Evolutional changes of cortical hypometabolism in West’s syndrome

The association between changes on serial PET studies and the clinical course of 12 patients with newly diagnosed West’s syndrome is reported from the Departments of Pediatrics and Radiology, Nagoya University School of Medicine, Nagoya, Japan.

 West’s Syndrome Focal Cortical Hypometabolism Psychomotor

The association between changes on serial PET studies and the clinical course of 12 patients with newly diagnosed West’s syndrome is reported from the Departments of Pediatrics and Radiology, Nagoya University School of Medicine, Nagoya, Japan. PET with FDG revealed diffuse or focal cortical hypometabolism in 11 patients, whereas MRI showed abnormalities in only 5. In 7 patients with normal findings on a second PET, spasms ceased after treatment, whereas in 5 with persistent abnormalities on PET, spasms persisted or recurred or partial seizures developed. Patients with normal MRI and normal second PET studies had normal psychomotor development. [1]

COMMENT. PET has been found of value in the preoperative evaluation of patients with West’s syndrome [2]. It may also be used in the assessment of prognosis. See also Ped Neur Briefs March 1992 and Progress in Pediatric Neurology II, Chicago, PNB Publ, 1994, for further reference to PET and infantile spasms.

 Maeda N Watanabe K Negoro T Aso K Ohki T Ito K Evolutional changes of cortical hypometabolism in West’s syndrome Lancet 1994 Jun 25 343 8913 1620 1623 10.1016/S0140-6736(94)93065-1 7911927 Chugani HT Shields WD Shewmon DA Olson DM Phelps ME Peacock WJ Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment Ann Neurol 1990 Apr 27 4 406 413 10.1002/ana.410270408 2353794