1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-38-b 10.15844/pedneurbriefs-8-5-9 Perinatal Diseases Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Microcephaly after HI Encephalopathy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 1994 01 06 2016 8 5 38 39 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Early prediction of the development of microcephaly after hypoxic-ischemic encephalopathy in the full-term newborn

The development of microcephaly after hypoxic-ischemic cerebral injury in the full-term newborn was studied at the University of British Columbia, Vancouver, Canada.

 Hypoxic-Ischemic Cerebral Hypoxic-Ischemic Encephalopathy Head Circumference Ratios

The development of microcephaly after hypoxic-ischemic cerebral injury in the full-term newborn was studied at the University of British Columbia, Vancouver, Canada. Serial head circumference measurements obtained at 4, 8, and 18 months of age in 54 newborns suffering from acute, hypoxic-ischemic encephalopathy showed that a decrease in head circumference ratios of >3.1% between birth and 4 months of age was highly predictive of the development of microcephaly before 18 months. Head circumference ratios were actual head circumference/mean head circumference x 100%. They were correlated with severity of neonatal HIE and outcome at 18 months. [1]

COMMENT. A decreased rate of head growth in the first 4 months after acute, intrapartum HIE correlates with the later development of microcephaly and neurological sequelae in the full-term neonate as well as very low birth weight infants.

 Cordes I Roland EH Lupton BA Hill A Early prediction of the development of microcephaly after hypoxic-ischemic encephalopathy in the full-term newborn Pediatrics 1994 May 93 5 703 7 8165065