1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-27-a 10.15844/pedneurbriefs-8-4-4 Ataxia Syndromes Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Cerebellar Ataxia and Multiple Sclerosis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1994 01 06 2016 8 4 27 27 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Childhood multiple sclerosis: MR images and clinical variations in four Japanese cases

Clinical manifestations and MRI findings in four Japanese children with multiple sclerosis are reported from the Department of Pediatrics, Sapporo Medical University, Japan.

 Multiple Sclerosis Cerebellar Intention Tremor Polyradiculoneuropathy

Clinical manifestations and MRI findings in four Japanese children with multiple sclerosis are reported from the Department of Pediatrics, Sapporo Medical University, Japan. Three presented with gait ataxia and one developed cerebellar intention tremor within 2 months of an onset with weakness of the right arm and speech impairment. The age of onset of symptoms was at 7-12 years. All had optic neuritis. MRI showed multiple white matter lesions and demyelinating plaques in cerebral hemispheres, cerebellum and brain stem. CT abnormalities were indefinite or absent. [1]

COMMENT. MRI was more sensitive than CT in diagnosis of demyelination in these patients. One of the 4 children had presented with Devic disease and 2 years later developed chronic inflammatory demyelinating polyradiculoneuropathy. A survey of 55 pediatric patients with MS in Japan by Prof Y Fukuyama and associates (1991) had found peripheral nerve involvement in 10 (17%).

 Wakai S Watanabe Y Ichiki T Watanabe T Numata K Tachi N Childhood multiple sclerosis: MR images and clinical variations in four Japanese cases Brain Dev 1994 Jan-Feb 16 1 52 56 10.1016/0387-7604(94)90113-9 8059929