1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-32-a 10.15844/pedneurbriefs-8-4-12 Vascular Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Indomethacin for Prevention of IV Hemorrhage http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1994 01 06 2016 8 4 32 32 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial

Results of a multicenter randomized trial of low-dose indomethacin (0.1 mg/kg IV) in prevention of intraventricular hemorrhage (IVH) in very low birth weight infants are reported from Yale New Haven Hospital, CT; Brown University, Providence, RI; and Maine Medical Center, Portland, ME.

 Indomethacin Intraventricular Hemorrhage Cerebral Vasoconstrictor Effects

Results of a multicenter randomized trial of low-dose indomethacin (0.1 mg/kg IV) in prevention of intraventricular hemorrhage (IVH) in very low birth weight infants are reported from Yale New Haven Hospital, CT; Brown University, Providence, RI; and Maine Medical Center, Portland, ME. The incidence and severity of IVH were significantly lowered. Of 431 neonates enrolled, 25 (12%) treated and 40 (18%) controls developed IVH. Grade 4 IVH occurred in only 1 indomethacin-treated neonate and in 10 placebo-treated controls. [1]

COMMENT. Volpe JJ, Harvard Medical School, and Reynolds EOR and Meek J, University College, London, are concerned about the cerebral vasoconstrictor effects of indomethacin and the dangers of periventricular ischemic injury [2]. These authorities are reluctant to endorse wholesale treatment of low birth weight newborns with indomethacin.

 Ment LR Oh W Ehrenkranz RA Philip AG Vohr B Allan W Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial Pediatrics 1994 Apr 93 4 543 550 10.1097/00006254-199409000-00011 8134206 Volpe JJ Brain injury caused by intraventricular hemorrhage: is indomethacin the silver bullet for prevention? Pediatrics 1994 Apr 93 4 673 677 677-678 8134229