1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-07 10.15844/pedneurbriefs-8-1-12 Infectious Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Lyme Disease Neurologic Syndromes http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1994 01 06 2016 8 1 7 7 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Neurologic manifestations in children with North American Lyme disease

The neurologic manifestations and syndromes associated with Lyme disease are reported in 96 patients, ages 3 to 19 years, living on Long Island and referred to University Hospital, Stony Brook, New York.

 Lyme Disease Neurologic Syndromes Meningoradiculitis

The neurologic manifestations and syndromes associated with Lyme disease are reported in 96 patients, ages 3 to 19 years, living on Long Island and referred to University Hospital, Stony Brook, New York. All were seropositive for anti-B burgdorferi antibodies. One-third had no prior history of extraneural manifestations of Lyme disease (erythema migrans, arthritis, flulike symptoms, and arthralgias/myalgias), and 90% had no memory of a tick bite. The most frequent neurologic symptom was headache (in 71%), and the most common sign was facial palsy (14%). Sleep disturbance was reported in 7%, papilledema was present in 6%, diplopia in 2%, and 1 had a Guillain-Barre-like syndrome with a CSF protein of 231 mg/dL. Elevations in CSF protein (32-58 mg/dL) were found in 25 of 53 patients examined, and a mild lymphocytic pleocytosis in 15. Neurologic syndromes included encephalopathy, lymphocytic meningitis, cranial neuropathy, and pseudotumor cerebri. [1]

COMMENT. The clinical course of Lyme disease in most children in this study was milder and shorter than that reported for adults, and meningoradiculitis (Bannwarth’s syndrome) and peripheral neuropathy syndromes were rare. A pseudotumor cerebri syndrome appears to be unique to childhood Lyme disease. A first report of stroke caused by Lyme disease in North America involved a woman of 56 years. [2]

 Belman AL Iyer M Coyle PK Dattwyler R Neurologic manifestations in children with North American Lyme disease Neurology 1993 Dec 43 12 2609 2614 10.1212/WNL.43.12.2609 8255465 Reik L Jr Stroke due to Lyme disease Neurology 1993 Dec 43 12 2705 2707 10.1212/WNL.43.12.2705 8255484