1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-8-01 10.15844/pedneurbriefs-8-1-1 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Febrile Seizures and Temporal Lobe Epilepsy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1994 01 06 2016 8 1 1 1 Copyright: © 1994 The Author(s) 1994 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination

The histories of 67 patients with medial temporal lobe seizures controlled by temporal lobectomy at a mean age of 27 years were evaluated at Yale University and Epilepsy Center, West Haven CT; Graduate Hospital, Philadelphia; Dartmouth-Hitchcock Medical Center; and VA Center, White River Junction, VT.

 Febrile Seizures Temporal Lobe Epilepsy Electroencephalography

The histories of 67 patients with medial temporal lobe seizures controlled by temporal lobectomy at a mean age of 27 years were evaluated at Yale University and Epilepsy Center, West Haven CT; Graduate Hospital, Philadelphia; Dartmouth-Hitchcock Medical Center; and VA Center, White River Junction, VT. Forty-five (67%) had histories of febrile seizures without CNS infection before 5 years of age, and of these, 33 had complex febrile seizures which lasted longer than 30 minutes. Other risk factors included head trauma (10%), and birth trauma (3%). Mean age at onset of complex partial epilepsy was 9 years. Seizures had become progressively worse over time in 22 patients before surgery. [1]

COMMENT. Complex febrile seizures during infancy or early childhood are frequent antecedents of medial temporal lobe epilepsy developing in later childhood. An excellent response to surgery may be expected in adult patients with a temporal lobe epilepsy syndrome associated with a history of prolonged febrile seizures. These results confirm those reported recently from the Montreal Neurological Institute (see Ped Neur Briefs Nov 1993;7:87) and support Falconer’s original suggestion of a causal relation between febrile seizures and medial temporal sclerosis (Epilepsia 1971;12:13). Of 41 patients with adequate pathological examination and a history of febrile seizures, in the Dartmouth and Yale temporal lobe epilepsy study, 38 (93%) had mesial temporal sclerosis. [2]

 French JA Williamson PD Thadani VM Darcey TM Mattson RH Spencer SS Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination Ann Neurol 1993 Dec 34 6 774 780 10.1002/ana.410340604 8250525 Williamson PD French JA Thadani VM Kim JH Novelly RA Spencer SS Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology Ann Neurol 1993 Dec 34 6 781 787 10.1002/ana.410340605 8250526