1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-7-50-a 10.15844/pedneurbriefs-7-7-2 Movement Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Tic Severity and Psychological Function http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1993 01 07 2016 7 7 50 50 Copyright: © 1993 The Author(s) 1993 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tourette’s syndrome in monozygotic twins. Relationship of tic severity to neuropsychological function

The relationship between tic severity and neuropsychological function was examined in 12 monozygotic twin pairs with Tourette’s syndrome at the National Institute of Mental Health, Bethesda, MD.

 Psychological Function Tourette’s Syndrome Pathophysiology

The relationship between tic severity and neuropsychological function was examined in 12 monozygotic twin pairs with Tourette’s syndrome at the National Institute of Mental Health, Bethesda, MD. Children with more severe tic symptoms had poorer overall performance on psychological tests, and differences were significant on individual tests of attention, visuospatial perception, and motor function. In each twin pair, the twin with more severe tics had poorer global neuropsychological function. [1]

COMMENT. Tic severity and psychological function in children with Tourette’s syndrome appear to be influenced by nongenetic factors with a common pathophysiology. The authors found that disturbances of attention were a cardinal psychological feature of TS, but most neuro-psychological measures were close to normal means.

 Randolph C Hyde TM Gold JM Goldberg TE Weinberger DR Tourette’s syndrome in monozygotic twins. Relationship of tic severity to neuropsychological function Arch Neurol 1993 Jul 50 7 725 728 10.1001/archneur.1993.00540070045013 8323476