1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-7-06-a 10.15844/pedneurbriefs-7-1-9 Hemiplegic Syndromes Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Hemiplegia with Superior Sagittal Sinus Thrombosis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1993 01 07 2016 7 1 6 6 Copyright: © 1993 The Author(s) 1993 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Superior sagittal sinus thrombosis in a child with protein S deficiency

A 2-year-old boy who developed a thrombosis of the superior sagittal sinus due to inherited protein S deficiency is reported from the Hospital de Cruces, Vizcaya, Spain.

 Superior Sagittal Sinus Pneumonia Intravascular Coagulation

A 2-year-old boy who developed a thrombosis of the superior sagittal sinus due to inherited protein S deficiency is reported from the Hospital de Cruces, Vizcaya, Spain. While recovering from pneumonia, the patient had symptoms of an acute disseminated intravascular coagulation disorder associated with sinus thrombosis, left hemiparesis, focal seizures, and thrombosis of the left femoral vein. The paresis resolved within two months. [1]

COMMENT. Homozygous protein S deficiency, an autosomal dominant trait with partial penetrance, usually presents with purpura fulminans in the newborn period. Heterozygous cases are responsible for recurrent peripheral thromboembolisms mainly in adults. Cerebral venous thrombosis is a rare complication of protein S deficiency, but should be considered in the etiology of acute hemiparesis in children.

 Prats JM Garaizar C Zuazo E Lopez J Piñan MA Aragües P Superior sagittal sinus thrombosis in a child with protein S deficiency Neurology 1992 Dec 42 12 2303 5 10.1212/WNL.42.12.2303-a 1461385