1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-7-07-a 10.15844/pedneurbriefs-7-1-11 Encephalopathies Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Acute Encephalopathy of Obscure Origin http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1993 01 07 2016 7 1 7 7 Copyright: © 1993 The Author(s) 1993 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Coma associated with intense bursts of abnormal movements and long-lasting cognitive disturbances: an acute encephalopathy of obscure origin

Six previously healthy children who developed an acute encephalopathy several days after a prodromal illness are reported from the Hopital Bicetre, and Hopital Necker-Enfants Malades, Paris, France.

 Acute Encephalo-Pathy Several Prodromal Illnesses Orofacial Dyskinesia

Six previously healthy children who developed an acute encephalopathy several days after a prodromal illness are reported from the Hopital Bicetre, and Hopital Necker-Enfants Malades, Paris, France. Prodromal illnesses consisted of upper respiratory infection with fever, and headache and vomiting. Coma was the initial symptom in 4 patients. Abnormal movements included gesticulation, chewing, swallowing, orofacial dyskinesia, limb dystonia, and choreoathetosis. Rigidity was constant in 5 patients and intermittent in one. Seizures occurred in 2 patients. Recovery extended for several weeks and was characterized by a rapid return of motor function and persistent behavioral and cognitive disturbances. Four patients recovered fully, and two had mild sequelae. [1]

COMMENT. These cases with a favorable outcome were thought to represent a different syndrome from that described by Lyon, Dodge, and Adams, whose 16 patients died from an acute encephalopathy of obscure origin. Attempts at viral isolation and antibody detection were negative.

 Sébire G Devictor D Huault G Aicardi J Landrieu P Tardieu M Coma associated with intense bursts of abnormal movements and long-lasting cognitive disturbances: an acute encephalopathy of obscure origin J Pediatr 1992 Dec 121 6 845 51 10.1016/S0022-3476(05)80326-9 1447643