1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-69-b 10.15844/pedneurbriefs-6-9-7 Metabolic Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Metabolic Alterations in Multiple Sclerosis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 09 1992 01 07 2016 6 9 69 69 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo

Alterations in regional cerebral metabolism have been demonstrated by in vivo proton magnetic resonance spectroscopy of 8 children (7 - 16 years) with established multiple sclerosis at the Max-Planck-Institut fur biophysikalische Chemie, Postfach, and Abt.

 Metabolic Alterations Multiple Sclerosis Cortical Gray Matter

Alterations in regional cerebral metabolism have been demonstrated by in vivo proton magnetic resonance spectroscopy of 8 children (7 - 16 years) with established multiple sclerosis at the Max-Planck-Institut fur biophysikalische Chemie, Postfach, and Abt. Kinderheilkunde, Schwerpunkr Neuropadiatrie, Georg-August-Universitat, Gottingen, Federal Republic of Germany. MS plaques showed a decrease in N-acetylaspartate and creatines, and an increase in cholines and myo-inositol. Cortical gray matter related to MS lesions showed a reduction of N-acetylaspartate. Functional impairment in MS was linked to gross metabolic disturbances of neuronal cell chemistry. [1]

COMMENT. Proton magnetic resonance spectroscopy has revealed metabolic alterations associated with multiple sclerosis in focal lesions and in the adjacent cortex. The method could aid in the differentiation of MS plaques from other disorders and in monitoring response to therapy. For additional articles on MS in children. [2]

 Bruhn H Frahm J Merboldt KD Hanicke W Hanefeld F Christen HJ Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo Ann Neurol 1992 Aug 32 2 140 150 10.1002/ana.410320205 1324631 Millichap JG Progress in Pediatric Neurology 1991 507 510