1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-53-b 10.15844/pedneurbriefs-6-7-8 Cerebrovascular Disease Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Idiopathic Stroke http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1992 01 07 2016 6 7 53 54 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51

Of 4 children with idiopathic stroke syndrome examined at the Department of Neurosciences and Pediatrics, UMD-New Jersey Medical School and the University of Rochester Medical Center, all 4 were heterozygous for human leukocyte antigen (HLA-B51).

 Human Leukocyte Antigen Idiopathic Stroke Syndrome Varicella Zoster Virus Infection

Of 4 children with idiopathic stroke syndrome examined at the Department of Neurosciences and Pediatrics, UMD-New Jersey Medical School and the University of Rochester Medical Center, all 4 were heterozygous for human leukocyte antigen (HLA-B51). Control samples from 3 patients with non-idiopathic stroke syndrome failed to reveal the HAL-B51 marker. [1]

COMMENT. The finding of a common immunogenetic marker in children with idiopathic stroke syndrome suggests a genetic predisposition and susceptibility. The authors suggest that host factors, possibly triggered by transient viral precipitants, may contribute causally to these vascular occlusions.

Delayed onset hemiparesis and vascular thrombosis may occur approximately 6 weeks after primary varicella zoster virus infection and may explain some cases of misdiagnosed idiopathic stroke in children [2]. The importance of this clinical entity is emphasized in an editorial (Lancet June 13, 1992; 339:1449-1450). The prognosis was good regardless of therapy and all patients recovered completely or nearly completely. The MRI was more sensitive than CT or angiography in demonstrating infarction of the basal ganglia and/or internal capsule. The delay in onset of the hemiparesis may result from the time taken for the vascular media to be infected with the virus.

 Mintz M Epstein LG Koenigsberger MR Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51 Ann Neurol 1992 Jun 31 6 675 677 10.1002/ana.410310618 1514780 Bodensteiner JB Hille MR Riggs JE Clinical features of vascular thrombosis following varicella Am J Dis Child 1992 Jan 146 1 100 102 10.1001/archpedi.1992.02160130102029 1736633