1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-52-a 10.15844/pedneurbriefs-6-7-5 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant CSF ACTH Levels in Infantile Spasms http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1992 01 07 2016 6 7 52 52 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Brain-adrenal axis hormones are altered in the CSF of infants with massive infantile spasms

ACTH levels in CSF of 14 infants with massive infantile spasms were significantly lower than those of controls in a study from the University of Southern California and Childrens Hospital of Los Angeles, CA.

 Corticotropin-Releasing Pathophysiology Infantile Spasms

ACTH levels in CSF of 14 infants with massive infantile spasms were significantly lower than those of controls in a study from the University of Southern California and Childrens Hospital of Los Angeles, CA. Differences in Cortisol levels between patients and controls were not statistically significant. The authors postulate the involvement of the corticotropin-releasing hormone-ACTH-glucocorticoid regulatory loop in the pathophysiology of infantile spasms. [1]

COMMENT. Further studies of this type should help to determine the respective merits of low dose versus high dose ACTH therapy in infantile spasms. [2]

 Baram TZ Mitchell WG Snead OC 3rd Horton EJ Saito M Brain-adrenal axis hormones are altered in the CSF of infants with massive infantile spasms Neurology 1992 Jun 42 6 1171 1175 10.1212/WNL.42.6.1171 1318521 Millichap JG Progress in Pediatric Neurology 1991 30 34