1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-55-b 10.15844/pedneurbriefs-6-7-11 Metabolic and Toxic Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Cocaine Addiction and EEG in Infants http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1992 01 07 2016 6 7 55 56 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Electroencephalographic and behavioral-state studies in infants of cocaine-addicted mothers

Thirty-five consecutive infants of cocaine-addicted mothers hospitalized for a comprehensive health assessment and 51 healthy, age-matched infants were studied with electroencephalography at the Children’s Hospital of Philadelphia, PA.

 Cocaine Electroclinical Sleep Discordance Cerebral Infarction

Thirty-five consecutive infants of cocaine-addicted mothers hospitalized for a comprehensive health assessment and 51 healthy, age-matched infants were studied with electroencephalography at the Children’s Hospital of Philadelphia, PA. No definite EEG seizures were recorded in any of the patients. In infants of cocaine-addicted mothers there was a tendency for electroclinical sleep discordance, and the frequency of early acquisition of a mature pattern of quiet sleep (continuous, slow-wave sleep) was significantly higher than in the comparison group below conceptional age 45 weeks. The significance of precocious maturity of quiet sleep was unclear, but may indicate accelerated biological development. [1]

COMMENT. The authors suggest that the longitudinal assessment of sleep disturbance and its relation to later development might permit tracking of the long-term effects of prenatal exposure to cocaine. Other complications of cocaine exposure in utero are small head circumference, abnormal behavior, cerebral infarction or hemorrhage, seizures and SIDS.

 Legido A Clancy RR Spitzer AR Finnegan LP Electroencephalographic and behavioral-state studies in infants of cocaine-addicted mothers Am J Dis Child 1992 Jun 146 6 748 752 1595633