1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-48-a 10.15844/pedneurbriefs-6-6-11 Congenital Developmental Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Lissencephaly: EEG and Evoked Potentials http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 06 1992 01 07 2016 6 6 48 48 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. EEG and evoked potentials in a series of 21 patients with lissencephaly type I

The EEGs and evoked potentials were studied in 21 Dutch patients with lissencephaly type I at the Departments of Clinical Neurophysiology and Neurology, Juliana Children’s Hospital, The Hague, The Netherlands.

 Lissencephaly Slow-Wave Complexes Atypical Cortical Dysplasia

The EEGs and evoked potentials were studied in 21 Dutch patients with lissencephaly type I at the Departments of Clinical Neurophysiology and Neurology, Juliana Children’s Hospital, The Hague, The Netherlands. Compared to patients with atypical cortical dysplasia and to a control group the EEGs in the lissencephaly patients showed the following patterns significantly more often: (a) generalized fast activity (8-18/s) with an amplitude higher than 50 μV, (b) sharp- and slow-wave complexes with high amplitude (range 500 - 3000μV and (c) an alternating pattern consisting of bursts of sharp waves alternating with periods of electrocerebral depression. Short latency somatosensory evoked potentials in 10 patients after stimulation of the median nerve were abnormal. [1]

COMMENT. Lissencephaly may be differentiated from an atypical cortical dysplasia by CT and/or MRI. In addition, the EEG and evoked potentials may be of diagnostic value. Generalized fast activity and sharp- and slow-wave complexes were noted in 20 of the 21 lissencephaly patients and in only 1 of the 21 patients with atypical cortical dysplasia. An abnormal PET scan suggested the microscopic pathology confirmed at autopsy in an infant with lissencephaly and normal gross cortical structure. The clinical features were intractable seizures and developmental delay but normal head growth [2]. Radiographic and clinical variability within the 3 subtypes of lissencephaly are reviewed in 19 patients ages 1 day to 6 years. [3]

 de Rijk-van Andel JF Arts WF de Weerd AW EEG and evoked potentials in a series of 21 patients with lissencephaly type I Neuropediatrics 1992 Feb 23 1 4 9 10.1055/s-2008-1071302 1565217 Korobkin R Sarnat H Chugani H Neurology 1992 April 4 Suppl 3 354 Demos DS Neurology 1992 April 42 Suppl 3 286