1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-31-b 10.15844/pedneurbriefs-6-4-9 Movement Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Hormonal Influences on Tourette Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1992 01 07 2016 6 4 31 32 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Menstrual cycle-related fluctuations of tics in Tourette syndrome

A survey of 47 women with Tourette syndrome reported from the Section of Pediatric Neurology, Children’s Hospital of Wisconsin, Milwaukee, WI had an increase in tics beginning at menarche and recurring premenstrually.

 Tourette Syndrome Premenstrual Syndrome Thermal Stress

A survey of 47 women with Tourette syndrome reported from the Section of Pediatric Neurology, Children’s Hospital of Wisconsin, Milwaukee, WI had an increase in tics beginning at menarche and recurring premenstrually. A comparable number of patients had a decreased tic frequency during the postmenstrual period. The average age of symptom onset was 8 years and the average age of diagnosis was 13.8 years. No significant relationship was found between a change in tic frequency and other non-menstrual cycle-related female hormonal states such as premenstrual syndrome, oral contraceptive use, pregnancy and menopause. [1]

COMMENT. Thermal stress is another factor that might exacerbate Tourette syndrome and cause an increase in the frequency of tics [2]. When challenged with heat or exercise in climate controlled conditions a 17 year old boy showed a marked increase in frequency of tics. The patient reported that his tics became more severe whenever the weather became warmer, when he had a fever, or after vigorous exercise. He would have difficulty standing and often had to lie down because of the severity of head jerks and other tics.

 Schwabe MJ Konkol RJ Menstrual cycle-related fluctuations of tics in Tourette syndrome Pediatr Neurol 1992 Jan-Feb 8 1 43 6 10.1016/0887-8994(92)90051-Y 1558574 Lombroso PJ Mack G Scahill L King RA Leckman JF Exacerbation of Gilles de la Tourette’s syndrome associated with thermal stress: a family study Neurology 1991 Dec 41 12 1984 1987 10.1212/WNL.41.12.1984 1745360