1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-21-b 10.15844/pedneurbriefs-6-3-7 Infantile Spasms Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant MRI in Tuberous Sclerosis with Normal I.Q. http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 03 1992 01 07 2016 6 3 21 22 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cranial magnetic resonance imaging in patients with tuberous sclerosis and normal intellect

The number, size and distribution of cerebral hamartomas determined by MRI in 11 patients with tuberous sclerosis and normal intellect are reported from the Bath Unit for Research into Paediatrics, Royal United Hospital, Combe Park, Bath, Avon, England and Bristol MRI Centre, Frenchay Hospital, Bristol.

 Tuberous Sclerosis Cerebral Hamartomas Temporal Lobe

The number, size and distribution of cerebral hamartomas determined by MRI in 11 patients with tuberous sclerosis and normal intellect are reported from the Bath Unit for Research into Paediatrics, Royal United Hospital, Combe Park, Bath, Avon, England and Bristol MRI Centre, Frenchay Hospital, Bristol. Nine patients had between 2 and 9 cerebral tubers seen on MRI T2 weighted images, 7 had 1-5 subependymal nodules and 2 had normal scans. The hamartomas were at least 4 mm in size. The number of lesions found on the MRI may not be used to predict neurological outcome in tuberous sclerosis. Only 3 of the 11 patients had a history of seizures and all had normal intellect. [1]

COMMENT. The authors suggest that the wrong conclusions may be drawn if the number of lesions alone on cranial MRI is used to predict neurological outcome in tuberous sclerosis. Lesions seen on both MRI and CT may become less obvious with advancing age in patients with tuberous sclerosis. In the experience of these authors, individuals who reach 5 years of age with normal development do not develop mental handicap from tuberous sclerosis. While the number of cerebral hamartomas appears to be an unreliable predictor of clinical outcome it is possible that the distribution and size of lesions may be more helpful. Patients with temporal lobe or occipital lobe hamartomas are most likely to have seizures or EEG abnormalities. Tuberous sclerosis was the cause of infantile spasms in 10% of cases treated in Finland (see Ped Neurol Briefs April 1990) but in only 2% reported from China. [2]

 Webb DW Thomson IL Osborne JP Cranial magnetic resonance imaging in patients with tuberous sclerosis and normal intellect Arch Dis Child 1991 Dec 66 12 1375 1377 10.1136/adc.66.12.1375 1776879 Feng YK Liu XQ Sha Y Liu PS Infantile spasms. A retrospective study of 105 cases Chinese Med J 1991 May 104 5 416 421 1652408