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<front>
<journal-meta>
<journal-id journal-id-type="issn">1043-3155</journal-id>
<journal-id journal-id-type="nlm-ta">Pediatr Neurol Briefs</journal-id>
<journal-id journal-id-type="pmc">pedneurbriefs</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr Neurol Briefs</journal-id>
<journal-title-group>
<journal-title>Pediatric Neurology Briefs</journal-title>
<abbrev-journal-title>Pediatr Neurol Briefs</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2166-6482</issn>
<issn pub-type="ppub">1043-3155</issn>
<issn-l>2166-3155</issn-l>
<publisher>
<publisher-name>Pediatric Neurology Briefs Publishers</publisher-name>
<publisher-loc>Chicago, IL, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">PNB-6-17</article-id>
<article-id pub-id-type="doi">10.15844/pedneurbriefs-6-3-1</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Febrile Convulsions</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Neurology</subject>
<subject>Pediatrics</subject>
<subject>Nervous System Diseases</subject>
<subject>Child Development</subject>
<subject>Brain Diseases</subject>
<subject>Neurosurgery</subject>
<subject>Child</subject>
<subject>Infant</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Recurrence of Febrile Seizures</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0173-7931</contrib-id>
<name>
<surname>Millichap</surname>
<given-names>J. Gordon</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref>
</contrib>
</contrib-group>
<aff id="AF0001">
<label>1</label>Division of Neurology, Children&#x0027;s Memorial Hospital, Chicago, IL</aff>
<aff id="AF0002">
<label>2</label>Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL</aff>
<author-notes>
<corresp id="cor1"><label>&#x002A;</label>Correspondence: Dr. J. Gordon Millichap, E-mail: <email xlink:href="jgmillichap@northwestern.edu">jgmillichap@northwestern.edu</email>
</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="print">
<month>03</month>
<year>1992</year>
</pub-date>
<pub-date date-type="pub" publication-format="electronic">
<day>01</day>
<month>07</month>
<year>2016</year>
</pub-date>
<volume>6</volume>
<issue>3</issue>
<fpage>17</fpage>
<lpage>17</lpage>
<permissions>
<copyright-statement>Copyright: &#x00A9; 1992 The Author(s)</copyright-statement>
<copyright-year>1992</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This work is licensed under the <uri xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</uri>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<related-article id="R1" related-article-type="commentary-article" ext-link-type="doi" xlink:href="10.1111/j.1469-8749.1992.tb08559.x" vol="34" page="15">
<article-title>Seizure recurrence after a first febrile seizure: a multivariate approach</article-title>
</related-article>
<abstract abstract-type="web-summary" specific-use="electronic-only">
<p>The predictive value of multiple clinical variables for febrile seizure recurrence was assessed in a follow-up study of 155 Dutch children at the Department of Paediatrics, University Hospital and Sophia Children&#x2019;s Hospital, Rotterdam, The Netherlands.</p>
</abstract>
<kwd-group>
<kwd>Febrile Seizure</kwd>
<kwd>Cerebral Palsy</kwd>
<kwd>Sodium Valproate</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p>The predictive value of multiple clinical variables for febrile seizure recurrence was assessed in a follow-up study of 155 Dutch children at the Department of Paediatrics, University Hospital and Sophia Children&#x2019;s Hospital, Rotterdam, The Netherlands. Children between 6 months and 5 years presenting with a first febrile seizure and a body temperature of 38.5c or higher but without intracranial infection or defined cause were included. Those with a history of nonfebrile seizures or with neurological abnormalities such as cerebral palsy and mental retardation were excluded as were those treated with continuous phenobarbitone or sodium valproate. Of these initially untreated children 37% had 1, 30% had 2, and 17% had 3 or more recurrences. The highest risk period for recurrence was during the 6 months after a seizure and the lowest risk was after 24 months freedom from seizures. The younger the child at the 2nd and 3rd seizures, the higher the likelihood of further recurrences. A first degree relative with any type of seizure predicted multiple recurrences of febrile seizures. A body temperature of 40c at initial seizure was associated with a lower risk as was an age of 30 months or older. [<xref ref-type="bibr" rid="CIT0001">1</xref>]</p>
<disp-quote>
<p><bold>COMMENT.</bold> The authors conclude that the predictive value of combined risk factors (age at onset, family history, height of fever) is superior to that of single variables. The association between elevated temperature and risk of recurrence is in keeping with the theory of a threshold of febrile seizures based on the height of the body temperature. [<xref ref-type="bibr" rid="CIT0002">2</xref>]</p>
</disp-quote>
</body>
<back>
<ref-list>
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</article>