1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-93-c 10.15844/pedneurbriefs-6-12-8 Brain Neoplasms Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Brain Radiotherapy and Cognition http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 12 1992 01 07 2016 6 12 93 94 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy

Cognitive function and school achievement were studied prospectively over 3 to 4 years in 19 children treated for brain tumors with whole-brain radiotherapy at the Children’s Hospital, Philadelphia, PA.

 Brain Tumors Whole-Brain Radiotherapy Chemotherapy

Cognitive function and school achievement were studied prospectively over 3 to 4 years in 19 children treated for brain tumors with whole-brain radiotherapy at the Children’s Hospital, Philadelphia, PA. Fourteen children also received adjuvant chemotherapy. A significant drop in IQ was seen among children with non-cortical tumors who received whole-brain radiotherapy with or without chemotherapy and who were treated before age 7. IQ did not decrease significantly in survivors treated after age 7. The IQ fell from a baseline of 104 to 92 at follow-up. [1]

COMMENT. All children younger than 7 years in this group were receiving special education at follow-up and 50% of the children over 7 years at diagnosis were receiving supplemental educational services. Increased fatiguability could be another reason for the poor school performance in these children.

 Radcliffe J Packer RJ Atkins TE Bunin GR Schut L Goldwein JW Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy Ann Neurol 1992 Oct 32 4 551 554 10.1002/ana.410320411 1456739