1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-93-b 10.15844/pedneurbriefs-6-12-7 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Valproate and EEG Abnormalities http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 12 1992 01 07 2016 6 12 93 93 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Valproate acute administration, EEG epileptic abnormalities, and ammonemia

The effect of valproate on EEG epileptic abnormalities was investigated at the Institute of Neurophysiology, Genoa, Italy.

 Valproate Ammonia EEG Abnormalities

The effect of valproate on EEG epileptic abnormalities was investigated at the Institute of Neurophysiology, Genoa, Italy. Sixteen patients aged 14 to 44 years were administered a single (14-37 mg/kg) oral dose of magnesium valproate. At peak serum concentrations of 65-139 ug/ml of valproate, there were increases in spike wave frequency at 2, 3, 4 and 5 hours. The peak concentrations of ammonia ranged from 15-72 ug/1, with values exceeding normal in 13 determinations. The VPA and ammonia concentrations varied independently. The frequency of EEG epileptic abnormalities was not correlated with either the ammonemia level or the amount of variation in ammonemia concentration. [1]

COMMENT. A direct CNS drug action has been proposed to explain the quantitative EEG abnormalities in response to acute VPA administration and the stupor states in some patients. The stupor was not necessarily related to the increased ammonia concentration in the blood.

 Sannita WG Valproate acute administration, EEG epileptic abnormalities, and ammonemia Neurology 1992 Oct 42 10 2003 2005 10.1212/WNL.42.10.2003 1407583