1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-93-a 10.15844/pedneurbriefs-6-12-6 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Amantadine in Absence Epilepsy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 12 1992 01 07 2016 6 12 93 93 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Effect of add-on amantadine therapy for refractory absence epilepsy

Refractory absence epilepsy in 4 children was treated with amantadine as an add-on drug at the Tel Aviv University Sackler School of Medicine, Israel.

 Amantadine Minor Motor Seizures Absence Seizures

Refractory absence epilepsy in 4 children was treated with amantadine as an add-on drug at the Tel Aviv University Sackler School of Medicine, Israel. The patients responded within 1 week and remained free of symptoms for 27-36 months without adverse effects. The dosage was 5-7 mg/kg per day given twice a day up to a maximum of 200 mg daily. [1]

COMMENT. Amantadine was initially used by Shields et al. in the treatment of 10 children with minor motor seizures refractory to medications. Myoclonic seizures and atypical absence seizures responded well. [2]

 Shahar EM Brand N Effect of add-on amantadine therapy for refractory absence epilepsy J Pediatr 1992 Nov 121 5 Pt 1 819 821 10.1016/s0022-3476(05)81922-5 1432438 Shields WD Lake JL Chugani HT Amantadine in the treatment of refractory epilepsy in childhood: an open trial in 10 patients Neurology 1985 Apr 35 4 579 581 3920549