1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-84 10.15844/pedneurbriefs-6-11-6 Neurocutaneous Syndromes Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Seizures and IQ in Tuberous Sclerosis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 11 1992 01 07 2016 6 11 84 84 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Seizures and intellectual disability associated with tuberous sclerosis complex in the west of Scotland

The relationship of seizures to intellectual disability was examined in 104 patients with tuberous sclerosis ascertained from the total population of the West of Scotland and reported from the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland.

 Tuberous Sclerosis Intellectual Disability Infantile Spasms

The relationship of seizures to intellectual disability was examined in 104 patients with tuberous sclerosis ascertained from the total population of the West of Scotland and reported from the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland. Detailed analysis of the seizures was confined to the 52 patients who were born after the 1st of July, 1966: 4 (8%) had no seizures and normal intelligence. Of the 48 patients with seizures, 18 (35%) had normal intelligence, 6 (12%) had moderate intellectual disability, and 24 (45%) had severe intellectual disability. Seizures were significantly associated with intellectual disability. No patient who developed seizures after the age of 5 years was intellectually impaired. Most individuals with intellectual disability presented with infantile spasms or other seizures under 1 year of age, or had multiple seizure types. A higher incidence of intellectual disability was found among individuals who had more than 1 seizure type. Also, children with TS whose first seizure is febrile have a high risk of developing intellectual disability. [1]

COMMENT. Several papers on tuberous sclerosis were presented at the 6th Congress of the International Child Neurology Association, November, 1992, Buenos Aires, Argentina. Laan LA et al. Rotterdam, found vigabatrin in therapy of resistant epilepsy with tuberous sclerosis to be valuable, if given early in childhood. Calderon-Gonzalez R et al. of Monterrey, Mexico, found 7 of 27 children (26%) with TS had infantile autism evident by 3.5 years of age. Rett syndrome was associated with tuberous sclerosis in 2 patients reported by Philippart M of Pomona, California. Curatolo P et al. of Rome, Italy reported topographic spike mapping of the EEG in TS which showed that “generalized” spike-and-wave discharges were of focal origin. [2]

 Shepherd CW Stephenson JBP Seizures and intellectual disability associated with tuberous sclerosis complex in the west of Scotland Dev Med Child Neurol 1992 Sep 34 9 766 774 10.1111/j.1469-8749.1992.tb11515.x 1526347 Curatolo P Pediatr Neurol 1992 Sept/Oct 8 344 411 10.1016/0887-8994(92)90088-G