1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-82-a 10.15844/pedneurbriefs-6-11-2 Toxic Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Hemolytic-Uremic Encephalopathy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 11 1992 01 07 2016 6 11 82 82 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome

Twenty-seven children, ages 6 months - 13 years, with encephalopathy complicating hemolytic-uremic syndrome are reported from The University of British Columbia, Vancouver, Canada.

 Encephalopathy Hemolytic-Uremic Syndrome Antimotility Agent

Twenty-seven children, ages 6 months - 13 years, with encephalopathy complicating hemolytic-uremic syndrome are reported from The University of British Columbia, Vancouver, Canada. Seventeen had seizures and 2 died. An increased risk for developing a neurological manifestation was correlated with the female sex, the prolonged use of an antimotility agent (e.g. codeine, anticholinergic drugs) and an increased hemoglobin. [1]

COMMENT. These authors have previously found an association between the prolonged use of antimotility drugs and the likelihood for progression of E coli enteritis to hemolytic-uremic syndrome. Systemically absorbed verotoxins are thought to be responsible for the multiple organ involvement. A food reservoir and improper handling are the most likely vehicles for transmission of the E coli.

 Cimolai N Morrison BJ Carter JE Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome Pediatrics 1992 Oct 90 4 616 621 1408519