1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-87 10.15844/pedneurbriefs-6-11-11 Anticonvulsant Drugs Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Vigabatrin Intractable Epilepsy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 11 1992 01 07 2016 6 11 87 88 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Vinyl GABA (vigabatrin): Relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children

The relationship between vigabatrin dosage and plasma concentrations, platelet GABA-transaminase inhibition and seizure reduction in 16 children with refractory epilepsy was studied at the University of Cantabria, Santander, Spain.

 Vigabatrin Intractable Epilepsy Tonic-Clonic Seizures

The relationship between vigabatrin dosage and plasma concentrations, platelet GABA-transaminase inhibition and seizure reduction in 16 children with refractory epilepsy was studied at the University of Cantabria, Santander, Spain. Vigabatrin dosages of 57 mg/kg/day and plasma concentrations of 8 mg/L reduced the GABA-T activity from 13.9 to 5.1 and seizures were reduced from 51 to 22 per month. Seizure reduction was correlated with the dosage but not with the plasma concentration or with platelet GABA inhibition. The initial dose of vigabatrin recommended was 50 mg/kg/day and was increased to 75 or 100 mg/kg/day. [1]

COMMENT. A study of vigabatrin in 43 children with intractable epilepsy is reported from the Royal Liverpool Children’s Hospital, England. The results showed that complex partial seizures, with or without secondary generalization, responded best with more than 1/2 achieving a greater than 50% reduction. Generalized tonic-clonic seizures also improved. Absence or myoclonic seizures were not benefited. Only 4 patients (10%) were seizure free on monotherapy with vigabatrin. [2]

In a study of 45 patients ages 2-21 years treated with vigabatrin in Paris, France, 20 (44%) showed no benefit and 24% were well controlled. Partial seizures were most responsive.

 Arteaga R Herranz JL Valdizan EM Armijo JA Vinyl GABA (vigabatrin): Relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children Epilepsia 1992 Sep-Oct 33 5 923 931 1396437 Gibbs JM Appleton RE Rosenbloom L Vigabatrin in intractable childhood epilepsy: a retrospective study Pediatr Neurol 1992 Sep-Oct 8 5 338 340 10.1016/0887-8994(92)90086-E 1418176