1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-6-80-a 10.15844/pedneurbriefs-6-10-9 Eye Movement Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Periodic Alternating Gaze and Cerebellar Dysgenesis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 1992 01 07 2016 6 10 80 80 Copyright: © 1992 The Author(s) 1992 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Periodic alternating gaze deviation in infancy

Two children with periodic alternating gaze deviation, presenting at birth in 1 patient and at 2 months in the other, are reported from the New England Medical Center, Tufts University, Boston, MA.

 Periodic Alternating Gaze Cranial Fossa Neuroblastoma

Two children with periodic alternating gaze deviation, presenting at birth in 1 patient and at 2 months in the other, are reported from the New England Medical Center, Tufts University, Boston, MA. The eyes conjugately drifted from one side to the other. With the head stabilized, a regular nystagmus of low frequency and large amplitude was seen when the patient attempted to direct the eyes away from the gaze bias. Compensatory head turning was noted in both patients. MRI showed multiple congenital abnormalities of the posterior cranial fossa. In 1 patient a left renal aplasia and a right supra-adrenal neuroblastoma were diagnosed by ultrasonography and by resection at 4 weeks of age. [1]

COMMENT. The periodic alternating gaze phenomenon is rare and points to cerebellar disease, with malformation of the inferior cerebellar vermis as the specific underlying lesion. The association with neuroblastoma in 1 patient is a coincidence since symptoms of opsoclonus were not described.

 Legge RH Weiss HS Hedges TR 3rd Anderson ML Periodic alternating gaze deviation in infancy Neurology 1992 Sep 42 9 1740 1743 10.1212/WNL.42.9.1740 1513463