1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-5-55-a 10.15844/pedneurbriefs-5-7-9 Headache Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Blood Magnesium Levels in Migraine http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1991 01 07 2016 5 7 55 55 Copyright: © 1991 The Author(s) 1991 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Blood magnesium levels in migraine

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n=38) and with aura (n=6) and for comparison, in a group of patients suffering from chronic tension-type headache (n=25) as well as a group of control patients (n=19) at the Headache Unit, Citadelle University of Liege, Liege, Belgium.

 Serum Magnesium Levels Erythrocytes Premenstrual Syndrome

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n=38) and with aura (n=6) and for comparison, in a group of patients suffering from chronic tension-type headache (n=25) as well as a group of control patients (n=19) at the Headache Unit, Citadelle University of Liege, Liege, Belgium. Serum magnesium levels were not significantly different between the four groups of patients, whereas magnesium levels in erythrocytes were significantly reduced in the group of migraineurs without aura (1.87) compared with those with aura (2.1), patients with tension-type headache (2.03) and the controls (2.12). Normal values in the laboratory ranged from 2-2.8 mmol/1 in erythrocytes. [1]

COMMENT. The correlation between magnesium levels and migraine pathophysiology is speculative. The possible importance of magnesium in migraine is suggested by the finding of reduced magnesium in white blood cells in women with premenstrual syndrome and headaches and the benefits of oral treatment with magnesium in premenstrual headaches. The authors hypothesize that the reduction in erythrocyte magnesium may be due to an abnormal regulation of intracellular magnesium in migraine patients.

 Schoenen J Sianard-Gainko J Lenaerts M Blood magnesium levels in migraine Cephalalgia 1991 May 11 2 97 99 10.1046/j.1468-2982.1991.1102097.x 1860136