1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-5-22 10.15844/pedneurbriefs-5-3-8 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Methsuximide for Intractable Seizures http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 03 1991 01 07 2016 5 3 22 23 Copyright: © 1991 The Author(s) 1991 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Methsuximide for intractable childhood seizures

The use of methsuximide in 25 children with intractable epilepsy is reported from the Department of Neurology and School of Pharmacy, University of North Carolina, Chapel Hill.

 Methsuximide Focal Spikes Carbamazepine

The use of methsuximide in 25 children with intractable epilepsy is reported from the Department of Neurology and School of Pharmacy, University of North Carolina, Chapel Hill. In 15 patients methsuximide was well tolerated and resulted in a 50% or greater reduction in seizure frequency. The predominant seizure types were tonic, complex partial, secondary generalized and astatic/myoclonic. The EEG showed generalized slow spike and wave in 14 and focal spikes in three. Two developed hypersensitivity rashes, two had intractable hiccups and four reported nausea. Patients had failed therapy with phenobarbital, primidone, phenytoin, carbamazepine and valproic acid alone or in various combinations. Decreases in carbamazepine serum concentrations occurred after starting methsuximide as an adjunctive anti-epileptic. [1]

COMMENT. Methsuximide has been reported of benefit in the treatment of petit mal, partial myoclonic, atonic and tonic seizures. As monotherapy methsuximide is not well established, but as an adjunct therapy further trials should be considered. Skin rash is not uncommon and methsuximide may be contraindicated in patients with a history of hypersensitivity reactions to other anticonvulsants.

 Tennison MB Greenwood RS Miles MV Methsuximide for intractable childhood seizures Pediatrics 1991 Feb 87 2 186 189 1987529