1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-4-29-a 10.15844/pedneurbriefs-4-4-6 Headache Syndromes Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Migraine-Related Stroke http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1990 01 08 2016 4 4 29 29 Copyright: © 1990 The Author(s) 1990 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Migraine-related stroke in the context of the International Headache Society classification of head pain

The diagnosis of migraine-related stroke is reviewed and case histories provided from the Center for Stroke Research, Department of Neurology, Henry Ford Hospital, Detroit, MI.

 Migraine-Related Stroke Migraine Ergot Therapy

The diagnosis of migraine-related stroke is reviewed and case histories provided from the Center for Stroke Research, Department of Neurology, Henry Ford Hospital, Detroit, MI. The collaborative group for the study of stroke in young women defined the relative risk for thrombotic stroke as two-fold for women with migraine when compared with a neighbor but not with a hospital control. In 448 total stroke cases 4% were attributed to migraine. The classification of migraine-related stroke is in three categories: 1) Coexisting stroke and migraine, 2) stroke with clinical features of migraine, and 3) migraine-induced stroke. Several arteriovenous malformations frequently masquerade as migraine with aura, oral contraceptives increase stroke risk and may cause coexisting stroke and migraine and ergot therapy for migraine is sometimes complicated by stroke. The pathogenesis of migraine-induced stroke includes coagulation, hemodynamic and neuronal factors. The initiation of a migraine attack is a primary neuronal phenomenon with metabolic and cerebral hemodynamic consequences. A low cerebral blood flow combined with factors which predispose to coagulopathy may lead rarely to intravascular thrombosis and migraine-induced cerebral infarction. [1]

COMMENT. Stroke associated with migraine in children is rare and is an indication for exclusion of an underlying structural cerebral lesion, e.g. arteriovenous malformation, congenital cerebral arterial occlusion, and encephalomalacia. Classical migraine associated with intractable epilepsy and multiple strokes has been described with mitochondrial encephalopathies. (Dvorkin GS, Andermann F et al, 1987).

 Welch KMA Levine SR Migraine-related stroke in the context of the International Headache Society classification of head pain Arch Neurol 1990 Apr 47 4 458 462 10.1001/archneur.1990.00530040114027 2181979