1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-4-27-a 10.15844/pedneurbriefs-4-4-3 Developmental Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Congenital Neurologic Malformations http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1990 01 08 2016 4 4 27 27 Copyright: © 1990 The Author(s) 1990 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Major congenital neurologic malformations. A 17-year survey

A 17-year survey of major congenital neurologic malformations among infants born in U.S. Army Hospitals worldwide from January 1, 1971 through December 31, 1987 is presented from the Neonatology Services, Walter Reed Army Medical Center, Washington, DC and Travis Grant USAF Medical Center, Travis Air Force Base, CA.

 Congenital Neurologic Malformations Spina Bifida Anencephaly

A 17-year survey of major congenital neurologic malformations among infants born in U.S. Army Hospitals worldwide from January 1, 1971 through December 31, 1987 is presented from the Neonatology Services, Walter Reed Army Medical Center, Washington, DC and Travis Grant USAF Medical Center, Travis Air Force Base, CA. From a population of 763 364 live-born and stillborn infants, 275 had anencephaly (0.36 per 1000 total births), 526 had spina bifida (0.69 per 1000), 112 had encephaloceles (0.15 per 1000), and 370 had hydrocephalus (0.48 per 1000 total births). The incidence of CNS defects among stillborn infants was 24 times greater than among live-born infants. There was a female preponderance of infants with anencephaly, spina bifida and encephalocele and a male predominance for hydrocephalus. Black infants were less likely than white infants to have spina bifida. Other congenital anomalies were associated in 20% of infants with anencephaly, 40% with encephaloceles, 37% with hydrocephalus, and 22% with spina bifida. [1]

COMMENT. The racial background of the patient population in this study closely resembled that of the United States as a whole and the results may reflect those of the U.S. In the past 20 years, declines in the frequencies of anencephaly and spina bifida have been noted in many countries, particularly in the British Isles. In the present study the incidence of neural tube defects decreased only among white female infants and no etiological factor could be implicated.

 Wiswell TE Tuttle DJ Northam RS Simonds GR Major congenital neurologic malformations. A 17-year survey Am J Dis Child 1990 Jan 144 1 61 67 10.1001/archpedi.1990.02150250071035 2403749