1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-3-93-a 10.15844/pedneurbriefs-3-12-5 Neurocutaneous Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Neurofibromatosis and the MRI http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 12 1989 01 08 2016 3 12 93 93 Copyright: © 1989 The Author(s) 1989 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A new sign of neurofibromatosis on magnetic resonance imaging of children

The MRI was abnormal in seven of ten children with clinically proved neurofibromatosis reported from the Department of Radiology, the Oregon Health Sciences University, Portland, and the Departments of Neurology, Pediatrics and Radiology, University of Miami School of Medicine.

 Neurofibromatosis Abnormalities Neurologic

The MRI was abnormal in seven of ten children with clinically proved neurofibromatosis reported from the Department of Radiology, the Oregon Health Sciences University, Portland, and the Departments of Neurology, Pediatrics and Radiology, University of Miami School of Medicine. Clinical diagnosis was based on six or more cafe-au-lait spots at least 1.5 cm in size. MRI was indicated because of mental retardation (5 patients), bilateral optic nerve tumors (1), shunt malfunction (1), learning disability (1), and possible brain tumor (2). The MRIs showed increased signal intensity on the T2-weighted images in the globus pallidus, brain stem, and cerebellum. The abnormalities most likely represented hamartomas. [1]

COMMENT. The MRI in this study was more revealing than the CT scan which was normal in all except one of the patients studied. The neurologic and developmental examinations showed no correlation with the MRI findings.

 Goldstein SM Curless RG Donovan Post MJ Quencer RM A new sign of neurofibromatosis on magnetic resonance imaging of children Arch Neurol 1989 Nov 46 11 1222 4 10.1001/archneur.1989.00520470086032 2510704