1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-3-74-a 10.15844/pedneurbriefs-3-10-2 Congenital Malformations Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Agenesis of the Corpus Callosum http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 1989 01 08 2016 3 10 74 74 Copyright: © 1989 The Author(s) 1989 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aicardi syndrome: postmortem findings

The postmortem findings in a two month old infant with the typical clinical features of Aicardi syndrome (i.e., infantile spasms, chorioretinal lacunae, and agenesis of the corpus callosum) are reported from the Division of Neurology, Saitama Children’s Medical Center, Saitama, Japan.

 Corpus Callosun Cortical Heterotropias Inmature Neurons

The postmortem findings in a two month old infant with the typical clinical features of Aicardi syndrome (i.e., infantile spasms, chorioretinal lacunae, and agenesis of the corpus callosum) are reported from the Division of Neurology, Saitama Children’s Medical Center, Saitama, Japan. The rostrum of the corpus callosum was absent and the roof of the dilated third ventricle was covered with a thin leptomeningeal membrane. Cortical heterotropias were found adjacent to the anterior horn of the right lateral ventricle and consisted of small immature neurons. The article includes a review of five autopsied patients with this syndrome previously reported in the literature. [1]

COMMENT. In these cases, a high incidence of EEG laterality and an asymmetry of pathological lesions are of interest. Three of six patients had focal agenesis of the corpus callosum and three had papilloma of the choroid plexus.

 Hamano S Yagishita S Kawakami M Ito F Maekawa K Aicardi syndrome: postmortem findings Pediatr Neurol 1989 Jul-Aug 5 4 259 61 2679585 10.1016/0887-8994(89)90088-X