1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2014-28-5-7 10.15844/pedneurbriefs-28-5-7 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Human Metapneumovirus and Status Epilepticus http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * http://orcid.org/0000-0002-0798-0131 Millichap John J. MD 1 2 Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 2014 31 10 2015 28 5 38 38 Copyright: © 2014 The Author(s) 2014 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Status epilepticus: a possible association with human metapneumovirus infection

Investigators at Cincinnati Children's Hospital, OH, report 2 toddlers, ages 15 and 18 months, with human metapneumovirus (hMPV) infection who presented in status epilepticus and later developed respiratory failure.

 Human Metapneumovirus Febrile Seizure Fatal Encephalitis

Investigators at Cincinnati Children's Hospital, OH, report 2 toddlers, ages 15 and 18 months, with human metapneumovirus (hMPV) infection who presented in status epilepticus and later developed respiratory failure. Both patients recovered over 2 weeks with no sequelae. Infection with hMPV should be considered as a cause of seizures or encephalitis with respiratory symptoms in infants and children. [1]

COMMENTARY. Neurological complications of human metapneumovirus infection are not mentioned in the 2012 edition of the AAP Redbook [2], and a review of seizures and hMPV in PubMed uncovers few reports. One earlier study reports an incidence of 6.3% of hMPV cases associated with seizures compared to 0.7% of patients infected with RSV (p = 0.031). hMPV may be associated with a spectrum of CNS disease ranging from febrile seizure to status epilepticus and severe, fatal encephalitis [3].

Webster DL Gardner AH Dye TJ Chima RS Status epilepticus: a possible association with human metapneumovirus infection Pediatrics 2014 Mar 133 3 e747 50 10.1542/peds.2013-0929 24515507 AAP Pickering LK Human Metapneumovirus Red Book: 2012 Report of the Committee on Infectious Diseases 2012 29th ed Elk Grove Village, IL AAP 509 10 Arnold JC Singh KK Milder E Spector SA Sawyer MH Gavali S Human metapneumovirus associated with central nervous system infection in children Pediatr Infect Dis J 2009 Dec 28 12 1057 60 10.1097/INF.0b013e3181acd221 19755929