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<front>
<journal-meta>
<journal-id journal-id-type="issn">1043-3155</journal-id>
<journal-id journal-id-type="nlm-ta">Pediatr Neurol Briefs</journal-id>
<journal-id journal-id-type="pmc">pedneurbriefs</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr Neurol Briefs</journal-id>
<journal-title-group>
<journal-title>Pediatric Neurology Briefs</journal-title>
<abbrev-journal-title>Pediatr Neurol Briefs</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2166-6482</issn>
<issn pub-type="ppub">1043-3155</issn>
<issn-l>2166-3155</issn-l>
<publisher>
<publisher-name>Pediatric Neurology Briefs Publishers</publisher-name>
<publisher-loc>Chicago, IL, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">PNB-2014-28-1-7</article-id>
<article-id pub-id-type="doi">10.15844/pedneurbriefs-28-1-7</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Traumatic Brain Injury</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Neurology</subject>
<subject>Pediatrics</subject>
<subject>Nervous System Diseases</subject>
<subject>Child Development</subject>
<subject>Brain Diseases</subject>
<subject>Neurosurgery</subject>
<subject>Child</subject>
<subject>Infant</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Neurological Deterioration After Mild TBI</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0173-7931</contrib-id>
<name>
<surname>Millichap</surname>
<given-names>J. Gordon</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0798-0131</contrib-id>
<name>
<surname>Millichap</surname>
<given-names>John J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
</contrib-group>
<aff id="AF0001">
<label>1</label>Division of Neurology, Ann &#x0026; Robert H. Lurie Children&#x0027;s Hospital of Chicago, Chicago, IL</aff>
<aff id="AF0002">
<label>2</label>Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL</aff>
<author-notes>
<corresp id="cor1">
<label>&#x002A;</label>Correspondence: Dr. J. Gordon Millichap, E-mail: <email xlink:href="jgmillichap@northwestern.edu">jgmillichap@northwestern.edu</email>
</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="print">
<month>01</month>
<year>2014</year>
</pub-date>
<pub-date date-type="pub" publication-format="electronic">
<day>31</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>28</volume>
<issue>1</issue>
<fpage>6</fpage>
<lpage>6</lpage>
<permissions>
<copyright-statement>Copyright: &#x00A9; 2014 The Author(s)</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This work is licensed under the <uri xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</uri>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<related-article id="R1" related-article-type="commentary-article" ext-link-type="doi" xlink:href="10.1227/NEU.0000000000000105" vol="73" page="753">
<article-title>Delayed neurological deterioration after mild head injury: Cause, temporal course, and outcomes</article-title>
</related-article>
<abstract abstract-type="web-summary" specific-use="electronic-only">
<p>Investigators from UMDNJ-New Jersey Medical School, Newark, NJ, studied the cause, course, and outcomes of 757 patients who were admitted over 54 months following mild head injury (MHI) complicated by intracranial hemorrhage (ICH).</p>
</abstract>
<kwd-group>
<kwd>Mild Head Injury</kwd>
<kwd>Delayed Neurological Deterioration</kwd>
<kwd>Neurological Deterioration</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p>Investigators from UMDNJ-New Jersey Medical School, Newark, NJ, studied the cause, course, and outcomes of 757 patients who were admitted over 54 months following mild head injury (MHI) complicated by intracranial hemorrhage (ICH). Of these, 31 (4.1%) experienced delayed neurological deterioration (DND)(Glasgow Coma Scale score decrease &#x003E;2); 87% deteriorated within 24 hours of admission, 68% had progressive ICH, 32% had medical causes for DND, and 23% died. Factors associated with mortality included age &#x003E;60 years, coagulopathy, and change in Marshall CT classification. In adolescents and adults the incidence of DND is low but carries significant morbidity and mortality if it results from progressive ICH. [<xref ref-type="bibr" rid="CIT0001">1</xref>]</p>
<p>COMMENTARY. This study shows that the majority (96%) of adult and adolescent patients with mild head injury plus ICH has a good prognosis and remains stable without neurological decline. In the 4% with delayed neurological deterioration, 87% deteriorated within the first 24 hours, mainly because of a progressive ICH. Coagulopathy is an important risk factor and the diagnosis and correction during transmission to a trauma center improves prognosis [<xref ref-type="bibr" rid="CIT0002">2</xref>]. Since age (&#x003E;60 years) is found to be a risk factor [<xref ref-type="bibr" rid="CIT0003">3</xref>], children and adolescents may be expected to carry a low risk of delayed neurological deterioration. The following study, however, emphasizes a residual cognitive disability in TBI children aged 7-18 years.</p>
<p>
<bold>Residual Cognitive Disability in Children with TBI</bold>. On admission to inpatient rehabilitation, patients with TBI had more cognitive disability than those with other injuries, and TBI patients had significant residual cognitive disability on discharge [<xref ref-type="bibr" rid="CIT0004">4</xref>].</p>
</body>
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