1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2012-26-6-2 10.15844/pedneurbriefs-26-6-2 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Celiac Disease and Increased Risk of Epilepsy http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 06 2012 01 11 2015 26 6 42 42 Copyright: © 2012 The Author(s) 2012 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study

Researchers at Orebro University Hospital, Orebro, and the Karolinska Institute, Stockholm, Sweden; and the Universities of Naples and Salerno, Italy examined the risk of developing epilepsy in a nationwide population-based sample of >28,000 patients with biopsy-verified celiac disease (CD).

 Hazard Ratio Celiac Disease Epilepsy

Researchers at Orebro University Hospital, Orebro, and the Karolinska Institute, Stockholm, Sweden; and the Universities of Naples and Salerno, Italy examined the risk of developing epilepsy in a nationwide population-based sample of >28,000 patients with biopsy-verified celiac disease (CD). The absolute risk of future epilepsy in patients with CD was 92/100,000 person-years (excess risk = 27/100,000 person-years), and the risk was independent of age. The hazard ratio (HR) for having at least 2 interactions with health care due to epilepsy was 1.41. In those patients with epilepsy treated with AEDs, the increased risk of epilepsy was 1.43. [1]

COMMENT. Celiac disease carries a moderately increased risk of epilepsy, and patients with epilepsy are at increased risk of future CD. The increased risk of epilepsy is present both before and after CD diagnosis, indicative of shared risk factors and supportive of an immunological etiology for epilepsy. [2]

Ludvigsson JF Zingone F Tomson T Ekbom A Ciacci C Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study Neurology 2012 May 1 78 18 1401 1407 10.1212/WNL.0b013e3182544728 22517096 Vezzani A French J Bartfai T Baram TZ The role of inflammation in epilepsy Nat Rev Neurol 2011 Jan 7 1 31 40 10.1038/nrneurol.2010.178 21135885