1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2012-26-10-10 10.15844/pedneurbriefs-26-10-10 Movement Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Long-Term Clinical Course of Tourette Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 2012 01 11 2015 26 10 80 80 Copyright: © 2012 The Author(s) 2012 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Long term clinical course of Tourette syndrome

Researchers at Catania University, and University Tor Vergata, Rome, Italy studied the course of Tourette syndrome (TS) after 10 years follow-up in 100 children.

 Tourette Syndrome Medication Severe Prognosis

Researchers at Catania University, and University Tor Vergata, Rome, Italy studied the course of Tourette syndrome (TS) after 10 years follow-up in 100 children. Of the “pure TS” group (n=38), 58% were unchanged, whereas 42% changed to TS+OCD phenotype. Of the “TS+ADHD” group (n=48), 62% changed to pure TS, 35% to TS+OCD, and 2% to TS+ADHD+OCD. Medication was required in 65%. Patients with comorbid condition at onset had a more severe prognosis and lower quality of life scores. [1]

COMMENT. Patients with pure TS at onset have a favorable prognosis, whereas patients with TS and comorbid disorders, ADHD and OCD, are at risk of impaired quality of life. TS presents with a variety of clinical phenotypes that may change over time. Appropriate treatment of ADHD in children with TS may prevent behavioral problems in adulthood. Comorbidity with ADHD, occurring in 50% of TS patients, causes more disability than motor tics alone [2]. Children with TS and ADHD have a 32% risk of learning disabilities. [3]

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