1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-25-82-a 10.15844/pedneurbriefs-25-11-2 Demyelinating Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Optic Neuritis, Abnormal MRI and Outcome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 11 2011 01 01 2016 25 11 82 82 Copyright: © 2011 The Author(s) 2011 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Childhood optic neuritis clinical features and outcome

Researchers at Birmingham Children’s Hospital, and Great Ormond Street and Evelina Children’s Hospitals, London, UK followed 44 children (female/male ratio 1.8; median age 10.9 years) with a first-episode optic neuritis for a median of 1 year (mean, 1 year 10 months).

 Optic Neuritis Visual Deficit Abnormal Initial MRI

Researchers at Birmingham Children’s Hospital, and Great Ormond Street and Evelina Children’s Hospitals, London, UK followed 44 children (female/male ratio 1.8; median age 10.9 years) with a first-episode optic neuritis for a median of 1 year (mean, 1 year 10 months). Maximal visual deficit was severe (<6/60) in 77%. Recovery was complete in 70%. At follow-up, 32% were diagnosed with MS (11/44) or neuromyelitis optica (NMO) (3/44). Cumulative probability of developing MS or NMO by 2 years after optic neuritis onset was 0.45. Gender, age, unilateral/bilateral optic neuritis, visual acuity severity, and CSF oligoclonal bands were non-predictive. Strong predictors of MS or NMO were relapsing optic neuritis (p<0.001) and an initial abnormal MRI (>1 brain T2 hyperintense lesion)(p<0.001). [1]

COMMENT. Pediatric acute onset optic neuritis has a good initial prognosis. An abnormal initial MRI or relapsing optic neuritis is predictive of MS or NMO.

Absoud M Cummins C Desai N Gika A McSweeney N Munot P Childhood optic neuritis clinical features and outcome Arch Dis Child 2011 Sep 96 9 860 862 10.1136/adc.2009.175422 20554767