1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-23-07-b 10.15844/pedneurbriefs-23-1-9 Language Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Autosomal Dominant Partial Epilepsy with Auditory Features http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 2009 01 12 2015 23 1 7 8 Copyright: © 2009 The Author(s) 2009 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Altered language processing in autosomal dominant partial epilepsy with auditory features

Auditory and language processing in 17 subjects with autosomal dominant partial epilepsy with auditory features (ADPEAF) was investigated by MRI, fMRI, and MEG and compared to 26 controls, in a study at Columbia University, New York.

 Autosomal Dominant Partial Epilepsy with Auditory Features Adolescence Structural Abnormality

Auditory and language processing in 17 subjects with autosomal dominant partial epilepsy with auditory features (ADPEAF) was investigated by MRI, fMRI, and MEG and compared to 26 controls, in a study at Columbia University, New York. Age of seizure onset was late childhood or adolescence. MRI revealed no structural abnormality, but fMRI and MEG showed reduced or delayed activation patterns in affected subjects. A previous report of a lateral temporal malformation in ADPEAF is not supported by this study, but the findings point to a functional impairment of language processing. [1]

COMMENT. Autosomal dominant partial epilepsy with auditory features is an idiopathic focal epilepsy syndrome with auditory symptoms or receptive aphasia. Families with this syndrome commonly have mutations in the LGI1 gene. These authors previously published a review of the genetics of 24 ADPEAF families with mutations in the LGI1 gene (Ped Neur Briefs Sept 2008;22:71).

Ottman R Rosenberger L Bagic A Kamberakis K Ritzl EK Wohlschlager AM Altered language processing in autosomal dominant partial epilepsy with auditory features Neurology 2008 Dec 9 71 24 1973 80 10.1212/01.wnl.0000336923.29538.5b 19064878