The long-term follow-up of seven patients with Landau-Kleffner syndrome (LKS) is reported from State University of Campinas, Brazil. All were males between age 8 and 27 years. Parents or patients were interviewed 3 to 16 years after disease onset. All had normal MRIs. All had interictal seizure discharges on the EEG, maximal on the temporal lobes in 5, and exacerbated in sleep. Age of disease onset was 3 to 9 years; 5 patients presented with seizures and 2 with language disorder. Seizures were focal motor in 6 patients; 3 had clonic orofacial movements, 2 had secondarily generalized seizures. Language disorder was insidious in onset in 4 and abrupt in 3. All patients had aphasia and verbal auditory agnosia. Two patients still had seizures at follow-up at 12 and 27 years of age, despite several antiepileptic drugs; seizures had resolved in 4. Language disorder had persisted in 3, it was partially in remission in 3, and had resolved in 1. Duration of aphasia was 2 to 8 years. One of 4 adult patients is employed, and 3 do not work independently. Three patients are under 13 years of age. Six of 7 patients have severe deficits in communication, and 3 have behavior problems. Only one patient has a normal quality of life. In six with limitations, aphasia/agnosia is the main problem. Shorter duration of aphasia correlates with better outcome. Five patients have normal EEGs, 6-17 years after disease onset; 2 still have abnormal EEGs and refractory seizures. [1]