Reversible Valproate Hepatotoxicity and Associated Mitochondrial Disease

Authors

  • J Gordon Millichap Northwestern University Feinberg School of Medicine

DOI:

https://doi.org/10.15844/pedneurbriefs-22-2-4

Keywords:

Hepatotoxicity, Mitochondrial, Alpers-Huttenlocher Syndrome

Abstract

A 2-year-old boy with seizures complicated by reversible valproate-induced hepatic failure was subsequently found to have mitochondrial polymerase g gene (POLG1) mutations typical of Alpers-Huttenlocher disease, in a study at Newcastle University, UK.

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Published

2008-02-01

Issue

Section

Seizure Disorders