1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-20-83-b 10.15844/pedneurbriefs-20-11-4 Brain Tumors Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Bone Mineral Density Reduction Following Irradiation of Brain Tumors http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 11 2006 01 02 2016 20 11 83 84 Copyright: © 2006 The Author(s) 2006 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bone mineral density is reduced in brain tumour patients treated in childhood

Total body bone mineral density (TBBMD) was measured by X-ray absorptiometry in 46 brain tumor patients aged from 3.8 to 28.7 years (mean 14.9 y) at a mean of 6.4 y (range 1.4-14.8 y) after end of treatment for brain tumor.

 Total Body Bone Mineral Density Brain Tumor Craniospinal Irradiation

Total body bone mineral density (TBBMD) was measured by X-ray absorptiometry in 46 brain tumor patients aged from 3.8 to 28.7 years (mean 14.9 y) at a mean of 6.4 y (range 1.4-14.8 y) after end of treatment for brain tumor. Tumors were astrocytic, grade 1, in 25 patients. Tumors were resected in 45 and biopsied in 1. Eleven received chemotherapy. Radiotherapy was cranial in 10 and craniospinal in 5. One third of the patients had low TBBMD (z scores < -2.0). Only combined craniospinal irradiation was significantly associated with low z scores, while cranial irradiation showed a borderline statistical association. [1]

COMMENT. The cause of the osteoporosis among children treated for brain tumor is multifactorial, and includes craniospinal irradiation. Other possible factors are glucocorticoid treatment, motor handicaps, and impaired nutrition. Early identification could lead to effective therapy.

Pietilä S Sievänen H Ala-Houhala H Koivisto AM Liisa Lenko H Mäkipernaa A Bone mineral density is reduced in brain tumour patients treated in childhood Acta Paediatr 2006 Oct 95 10 1291 1297 10.1080/08035250600586484 16982504