1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2-62-a 10.15844/pedneurbriefs-2-8-9 Neonatal Seizures Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Surgery for Neonatal-Onset Seizures http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1988 01 08 2016 2 8 62 62 Copyright: © 1988 The Author(s) 1988 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Surgical treatment of intractable neonatal-onset seizures: the role of positron emission tomography

Four children with intractable neonatal-onset seizures treated successfully by hemispherectomy at 1 1/2-5 years of age are reported from UCLA School of Medicine, Los Angeles, California.

 Neonatal-Onset Seizures Fluoro-D-Glucose Intractable Epilepsy

Four children with intractable neonatal-onset seizures treated successfully by hemispherectomy at 1 1/2-5 years of age are reported from UCLA School of Medicine, Los Angeles, California. Positron emission tomography (PET) with fluoro-D-glucose provided accurate localization of seizure foci whereas CT and MRI were either normal or showed mild generalized cerebral atrophy. The report illustrates the important role of PET in the evaluation of children with intractable epilepsy of neonatal onset. [1]

COMMENT. The criteria for hemispherectomy were as follows: 1. Intractable unilateral seizures with diffuse epileptic activity in the affected hemisphere. 2. Persistent neurologic deficit on the contralateral side. 3. Malfunction of the affected hemisphere and intact function of the opposite hemisphere as tested by interictal EEGs, evoked potentials, thiopental test, and PET. At UCLA the results of surgery are impressive: the patients were seizure-free for periods up to 1 1/2 years and 3 patients were off all anticonvulsants. The surgical approach to treatment of refractory seizures appears superior to the conservative method with potentially toxic anticonvulsant drugs. The authors are to be complemented for their aggressive approach and search for alternate forms of early treatment.

 Chugani HT Shewmon DA Peacock WJ Shields WD Mazziotta JC Phelps ME Surgical treatment of intractable neonatal-onset seizures: the role of positron emission tomography Neurology 1988 Aug 38 8 1178 1188 10.1212/WNL.38.8.1178 3261000