1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2-53-a 10.15844/pedneurbriefs-2-7-7 Developmental Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Hypomelanosis of Ito http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 1988 01 08 2016 2 7 53 53 Copyright: © 1988 The Author(s) 1988 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hypomelanosis of Ito. Neurological complications in 34 cases

The neurological complications in 34 Spanish children with hypomelanosis of Ito are described from the Paediatric Neurology Service, Hospital Infantil La Paz, and La Universidad Autonoma, Madrid, Spain.

 Hypomelanosis Angiomatous Nevi Fair-Skinned Individuals

The neurological complications in 34 Spanish children with hypomelanosis of Ito are described from the Paediatric Neurology Service, Hospital Infantil La Paz, and La Universidad Autonoma, Madrid, Spain. Most were referred because of mental retardation (65%) and seizures (53%), and the ages at time of the first visit were 2 months to 10 years. Skin lesions, observed within the first year of life in 70% of patients, consisted of hypomelanotic depigmented patches, cafe-au-lait spots, and angiomatous nevi; changes in hair color and alopecia also occurred. Noncutaneous abnormalities, observed in 94%, included macrocephaly, microcephaly, hemihypertrophy, kyphoscoliosis, coarse facial features, and hypertelorism. Autosomal dominant inheritance was demonstrated in some. [1]

COMMENT. The incidence of this disease was estimated at 1 per 1000 new patients consulting a pediatric neurology service, or 1 per 10,000 unselected patients in a children's hospital. It affects all races, but fair-skinned individuals may require a Woods lamp examination to detect the cutaneous lesions.

 Pascual-Castroviejo I López-Rodriguez L de la Cruz Medina M Salamanca-Maesso C Roche Herrero C Hypomelanosis of Ito. Neurological complications in 34 cases Can J Neurol Sci 1988 May 15 2 124 9 3383022