1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2-34 10.15844/pedneurbriefs-2-5-3 Headache Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Amaurosis Fugax and Migraine http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 1988 01 08 2016 2 5 34 34 Copyright: © 1988 The Author(s) 1988 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Amaurosis fugax in teenagers. A migraine variant

Amaurosis fugax, a sudden, transient monocular loss of vision resolving in 5 to 10 minutes, is reported in five teenagers from the British Columbia’s Children’s Hospital, Vancouver, BC, and The Hospital for Sick Children, Toronto, Canada.

 Transient Monocular Loss Internal Carotid Artery Cerebral Angiography

Amaurosis fugax, a sudden, transient monocular loss of vision resolving in 5 to 10 minutes, is reported in five teenagers from the British Columbia’s Children’s Hospital, Vancouver, BC, and The Hospital for Sick Children, Toronto, Canada. Four patients had a history of common migraine at other times or a family history of migraine. Unlike adults in whom amaurosis fugax is associated frequently with atherosclerosis of the internal carotid artery and a herald of stroke, these symptoms in children may represent a migraine variant, and cerebral angiography is usually unwarranted. [1]

COMMENT: The causes of amaurosis fugax are diverse and include carotid atheromatous disease, Raynaud’s disease, temporal arteritis, sickle cell anemia, optic nerve tumor, hysteria, as well as migraine. Patients who describe a characteristic mosaic or jigsaw pattern of transient monocular blindness are more likely to be suffering from migraine than carotid atheromatosis, especially in children and adolescents.

On the subject of migraine, Peroutka SJ of Stanford University Medical Center has demonstrated that a large number of migraine prophylactic agents, including propranolol, methysergide, cyproheptadine, and pizotifen, share an ability to interact with 5-hydroxytryptamine (serotonin) receptor subtypes in human brain. This property is offered as a method of selection of drugs for clinical trial in migraine. [2]

 Appleton R Farrell K Buncic JR Hill A Amaurosis fugax in teenagers. A migraine variant Am J Dis Child 1988 Mar 142 3 331 3 10.1001/archpedi.1988.02150030105032 3344721 Peroutka SJ Antimigraine drug interactions with serotonin receptor subtypes in human brain Ann Neurol 1988 May 23 5 500 4 10.1002/ana.410230512 2898916